Product Details
| Product Name:
GDC-0276 |
CAS No.:
1494581-70-2 |
| Purity:
99.77% |
Supply Ability:
10g |
| Release date:
2025/10/27 |
Product Introduction
Bioactivity
| Name | GDC-0276 |
| Description | GDC-0276 is an orally active, selective, and potent NaV1.7 inhibitor that can be used for the study of pain-related diseases. |
| In vitro | GDC-0276 is a potent, selective, reversible, orally active NaV1.7 inhibitor with an IC50 of 0.4 nM and a Ki of 1.1 nM. [1] |
| In vivo | In a mouse model of inherited erythromelalgia (IEM), GDC-0276 treatment showed a concentration-dependent reduction in nociceptive events with an EC50 of 1.7 μM. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 100 mg/mL (216.18 mM), Sonication is recommended.
|
| Keywords | NaV1.7 Electrophysiology | GDC-0276 | GDC 0276 |
| Inhibitors Related | Phenytoin sodium | Procaine | Lidocaine | Safinamide | Valproic Acid | Lidocaine hydrochloride | L-Aspartic aicd sodium | Mebeverine hydrochloride | Amitriptyline hydrochloride | Riluzole | Benzocaine | Tolperisone hydrochloride |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
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Price |
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Suppliers |
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$33.00/2mg |
VIP6Y
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TargetMol Chemicals Inc.
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2025-11-09 |
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$0.00/5mg |
VIP2Y
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2025-08-21 |
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$1.10/1g |
VIP5Y
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Shaanxi Dideu Medichem Co. Ltd
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2021-05-08 |
United States