GSK3368715 dihydrochloride NEW
| Price | $56 |
| Package | 1mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-11-04 |
Product Details
| Product Name: GSK3368715 dihydrochloride | CAS No.: 1628925-77-8 |
| Purity: 99.66% | Supply Ability: 10g |
| Release date: 2025/11/04 |
Product Introduction
Bioactivity
| Name | GSK3368715 dihydrochloride |
| Description | GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is an orally active and potent inhibitor of type I protein arginine methyltransferases (PRMTs), including PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8. It exhibits anticancer and antitumor activity and can be used to study advanced solid tumors. |
| In vitro | In the majority of 249 cancer cell lines representing 12 tumor types, GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) exhibits 50% or more growth inhibition relative to DMSO-treated cells[1]. |
| In vivo | GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) markedly inhibits the growth of BxPC3 xenografts at all tested doses, achieving tumor growth reductions of 78% and 97% at 150 mg/kg and 300 mg/kg, respectively[1]. |
| Storage | store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (9.1 mM), Sonication is recommended. H2O : 100 mg/mL (227.55 mM), Sonication is recommended. DMSO : 100 mg/mL (227.55 mM), Sonication is recommended. |
| Keywords | PRMT8 | PRMT6 | PRMT4 | PRMT3 | PRMT1 | HistoneMethyltransferase | Histone Methyltransferase | GSK-3368715 Dihydrochloride | GSK3368715 Dihydrochloride | GSK-3368715 | GSK3368715 | GSK 3368715 Dihydrochloride | GSK 3368715 | EPZ-019997 Dihydrochloride | EPZ-019997 | EPZ019997 | EPZ 019997 Dihydrochloride | EPZ 019997 |
| Inhibitors Related | MAK-683 hydrochloride | ORIC-944 | Tazemetostat | Piribedil | XY1 | UNC 0631 | MAK683 | EPZ015666 | iso-Azalansta | AMI-1 free acid | MS37452 | MRTX-1719 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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