hCAI/II-IN-2 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-27 |
Product Details
| Product Name: hCAI/II-IN-2 | CAS No.: 2480283-75-6 |
| Supply Ability: 10g | Release date: 2025/10/27 |
Product Introduction
Bioactivity
| Name | hCAI/II-IN-2 |
| Description | hCAI/II-IN-2 (compound 2b) is a highly effective dual inhibitor of human carbonic anhydrase I and II (hCA I/II), with Ki values of 40.97 nM for hCA I, 15.15 nM for hCA II, and 61.88 nM for hCA IX. With its anti-hypoxic properties, hCAI/II-IN-2 demonstrates activity against acute mountain sickness (AMS) and exhibits low cellular activity [1]. |
| In vitro | 'hCAI/II-IN-2 (compound 2b) (5-200 μM, 48 hours; HEK293T cells) exhibited no significant cytotoxic effects on HEK293T cells [1]. This was determined through a Cell Cytotoxicity Assay conducted on the embryonic kidney (HEK293T) cell line with compound concentrations ranging from 5 to 200 μM over a 48-hour incubation period, demonstrating no apparent cytotoxicity [1].' |
| In vivo | In an animal model study using male BLAB/c mice [1], the oral administration of a chemical compound at a dosage of 400 mg/kg over 14 days resulted in a 21.7% increase in survival time compared to the blank control group. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Inhibitors Related | Benzenesulfonamide | Urea | Sodium Dihydrogen Phosphate | Cyclamic acid sodium | Ellagic acid | Hydrochlorothiazide | Orthanilamide | Zonisamide | Tioxolone | 2-Methoxy-4-propylphenol | pNNP | Acesulfame |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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