Heptamidine NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-21 |
Product Details
| Product Name: Heptamidine | CAS No.: 94345-47-8 |
| Supply Ability: 10g | Release date: 2025/07/21 |
Product Introduction
Bioactivity
| Name | Heptamidine |
| Description | Heptamidine is an effective Pentamidine-related inhibitor of the calcium-binding protein S100B (Kd: 6.9 μM). It selectively kills melanoma cells with S100B over those without S100B. It is a useful tool for the investigation of Myotonic dystrophy. |
| In vitro | Heptamidine is a Pentamidine-S100B complex with two pentamidine molecules binding per monomer of S100B, acting as an inhibitor for S100B[1]. It rescues mis-splicing of minigene reporters in a HeLa cell DM1 model with an EC50 value of 15 μM. Compared to Propamidine and Pentamidine, Heptamidine (20 μM) does not significantly reduce CUG levels. It exhibits cytotoxicity at concentrations above 17.5 μM in HeLa cells expressing 960 CUG repeats[2]. |
| In vivo | Heptamidine (intraperitoneal injection; 20 or 30 mg/kg; 7 days) induces a dose-dependent reduction of exon 7a inclusion in HSALR mice, returning to wild-type levels (6±1%) at a 20 mg/kg dose. Myotonia is reduced from grade 3 to grade 1 (occasional myotonic discharge) or grade 0 at both 20 and 30 mg/kg [2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Heptamidine | calcium-binding protein S100B |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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