Product Details
| Product Name:
ZYF0033 |
CAS No.:
2380300-79-6 |
| Purity:
99.70% |
Supply Ability:
10g |
| Release date:
2025/11/10 |
Product Introduction
Bioactivity
| Name | ZYF0033 |
| Description | ZYF0033 is an orally effective small molecule inhibitor of hematopoietic progenitor kinase 1 (HPK1) that inhibits the phosphorylation of MBP proteins.HPK1-IN-22 promotes anticancer immune responses by decreasing the phosphorylation of SLP76 (serine 76), and has the potential to inhibit tumor growth and mediate immune responses. |
| In vitro | ZYF0033 (HPK1-IN-22) (100 nM, 24 h) reduces the phosphorylation of SLP76 (serine 376) in T cells, leading to HPK1 inhibition and increasing the proliferation of CD4+ and CD8+ T cells and the secretion of IFN-γ. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (172.93 mM), Sonication is recommended.
|
| Inhibitors Related | Sodium lauryl sulfoacetate | CMPD1 | SKLB-163 | MBM-55S | sodium lauroyl-α-hydroxyethyl sulfonate | RV01 | Takinib | NG25 | RMM-46 | Oleanolic Acid | Selonsertib | KY-05009 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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Recommended supplier
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Price |
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Suppliers |
Update time |
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$/ |
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States