Product Details
| Product Name: Icatibant Acetate | CAS No.: 138614-30-9 |
| Min. Order: 1KG | Purity: 99% |
| Supply Ability: 1T | Release date: 2025/10/08 |
| Product Name: | Icatibant Acetate |
| Synonyms: | HOE-140 (Icatibant);HOE140; ICATIBANT;HOE 140;CS-1399;Firazyr;HOE 140 SYNTHETIC >99% SELECTIVE B2 BRAD YKIN;d-arg-l-arg-l-pro-l-hyp-gly-l-(2-thienyl)ala-l-ser-d-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-l-(2α,3β,7aβ)-octahydro-1h-indole-2-carbonyl-l-arg;Icatibant acetate, D-Arg-L-Arg-L-Pro-L-Hyp-Gly-L-(2-thienyl)Ala-L-Ser-D-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-(2α,3β,7aβ)-octahydro-1H-indole-2-carbonyl-L-Arg;HOE 140 Acetate |
| CAS: | 138614-30-9 |
| MF: | C59H89N19O13S.C2H4O2 |
| MW: | 1364.59 |
| EINECS: | 206-141-6 |
| Product Categories: | |
| Mol File: | 138614-30-9.mol |
 | |
| Icatibant Acetate Chemical Properties |
| storage temp. | -20°C |
| solubility | DMSO:65.0(Max Conc. mg/mL);47.63(Max Conc. mM) Ethanol:0.25(Max Conc. mg/mL);0.18(Max Conc. mM) PBS (pH 7.2):10.0(Max Conc. mg/mL);7.33(Max Conc. mM) |
| form | A crystalline solid |
| color | White to off-white |
| InChIKey | HKMZRZUEADSZDQ-SUJPMXFINA-N |
| Safety Information |
| WGK Germany | 3 |
| MSDS Information |
| Icatibant Acetate Usage And Synthesis |
| Description | Although it is a rare disease, HAE is an autosomal dominant disorder that can be potentially life-threatening when swelling manifests itself within the upper airways. Antagonism of the constitutively expressed B2 receptor, therefore, would not only be beneficial in the treatment of HAE but also find application in inflammatory, allergic, and hyperalgesic disorders.Designed to possess enhanced metabolic stability with the inclusion of five non-proteinogenic amino acids, icatibant is a competitive and selective B2 receptor antagonist (devoid of activity against the inducible B1 receptor) with a Ki of 2.2±0.7 nM, and it is the first downstream targeting agent to receive regulatory approval. It joins purified C1 esterase inhibitor, danazol (an attenuated androgen), and tranexamic acid (an antifibrinolytic agent) as acute and prophylactic treatments for HAE. |
| Originator | Jerini (Germany) |
| Uses | Antagonist (bradykinin). |
| Uses | Icatibant Acetate is a bradykinin B2 receptor antagonist that has been recently approved for treatment of acute attacks of hereditary angioedema (HAE). |
| Definition | ChEBI: An acetate salt obtained by combining icatibant with acetic acid. Used for the treatment of acute attacks of hereditary angioedema in adult patients. |
| Brand name | Metastat (CollaGenex);Firazyr. |
| Biochem/physiol Actions | B2 bradykinin receptors are present in the sensory neurons. Activation of B2 receptor by bradykinin is associated with pro-inflammatory, pain producing and cardiovascular responses. HOE-140 is a selective B2 bradykinin receptor antagonist. Presence of HOE-140 suppresses the effects of bradykinin and has been shown to have anti-hyperalgesic response, particularly towards inflammatory pain. |
| Synthesis | The peptidomimetic is prepared by standard solidphase technology on Wang resin employing Fmoc chemistry. Following trifluoroacetic acid cleavage with appropriate scavengers and HPLC purification, icatibant is ultimately isolated as its acetate salt. |
Company Profile Introduction
Shandong Hanjiang Chemical Co., Ltd. is located in Zibo City, Shandong Province, China.
It is a biotechnology enterprise engaged in the R&D, production and sales of drugs, steroids, peptides, raw materials, vitamins, food additives, animal and plant extracts, cosmetics, pharmaceutical raw materials and intermediates. The company has complete experimental facilities. Advanced testing instruments ensure the stability of product quality from all aspects. The company has a complete sales service system, and its products are exported to countries all over the world. It has won a good international reputation for its excellent quality and excellent service. The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers, and constantly strict requirements,
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Our company supply high quality chemical products with the most competitive prices.
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