Product Details
| Product Name:
IDO1-IN-2 |
CAS No.:
2346614-58-0 |
| Supply Ability:
10g |
Release date:
2025/10/27 |
Product Introduction
Bioactivity
| Name | IDO1-IN-2 |
| Description | IDO1-IN-2 is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse), and 28 nM (rat), respectively. It has anti-cancer activity. |
| In vitro | IDO1-IN-2 has an IC50 of 249 nM for IDO1 wholr blood.IDO1-IN-2 inhibits amino-cyclobutarene-derived indoleamine-2,3-dioxygenase 1 (IDO1) Hela cellular with an IC50 of 49 nM. |
| In vivo | IDO1-IN-2 exhibits pharmacokinetic properties with a half-life (t1/2) of 3.7 hours, a clearance/bioavailable unbound clearance (CL/CLu) of 15/319 mL/min/kg, and bioavailability (F) of 63% in rats. In dogs, its half-life extends to 6 hours, with a CL/CLu of 6/88 mL/min/kg, and a bioavailability of 67%. Furthermore, IDO1-IN-2, administered at a dose of 100 mg/kg twice daily, effectively enhances therapeutic outcomes when used alongside anti-PD-1 monoclonal antibodies (mAb) in a mouse EMT6 tumor syngeneic model, demonstrating significant synergy in efficacy. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | IDO1-IN-2 | IDO-1-IN-2 | IDO1IN2 | IDO1 IN 2 | IDO1 |
| Inhibitors Related | Palmatine chloride | GNF-PF-3777 | Coptisine chloride | Necrostatin-1 | IDO-IN-7 | Indoximod | Palmatine | Epacadostat | β-Lapachone | IDO5L | 3-TYP | IDO-IN-12 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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