Ivermectin antiparasite API

【General Information】

Ivermectin is a new type of broad-spectrum, high efficiency and low toxicity antibiotic against parasites, especially nematodes and arthropods. But not for tapeworms, flukes and protozoa. Large ring lactone class parasite drug resistance to nematodes and the function of flooding killed by arthropods, is to increase the insect body inhibitory neurotransmitter gamma aminobutyric acid (GABA) release, and open the glutamic acid control Cl ion channels, strengthen the nerve membrane permeability of Cl, thereby blocking nerve signal transmission, nerve palsy, eventually lose muscle contraction ability, And cause the worm to die.

【Pharmacodynamics】

Since flukes and tapeworms do not use GABA as a transmitter, they lack glutamate-controlled CL channels. Therefore, this class of drugs has no effect on it. The peripheral neurotransmitter of mammals is acetylcholine. Although GABA is distributed in the central nervous system, it is relatively safe to use this class of drugs because it is not easy to cross the blood-brain barrier and has little effect on it.

The mechanism by which these drugs affect parasite reproduction is not well understood, but they reduce the number of ticks that lay eggs, make the eggs of C. ruminants abnormal, and make filamentous C. elegans (male and female) sterile.

Hebei ZB-Gamay Biological Technology Co.,Ltd, established in 2009, is a professional manufacturer of veterinary medicine. The company has invested more than 10 million RMB to build several advanced production lines, and has passed the national veterinary drug GMP enterprise acceptance.
The company has a number of patented technologies, and has more than 100 veterinary drug products that are highly competitive and are sold well all over the world.
The ZB-Gamay Group is across the fields of veterinary medicine, feed, breeding, and trade. It upholds the concept of honesty, cooperation, innovation, and common development.
Adhering to the business philosophy of "putting customers' rights first", Hebei ZB-Gamay Biological Technology Co., Ltd has created an integrated service process and professional service team to provide customers with professional and technical services, enhance the level of disease prevention and control of customers, and provide comprehensive solutions for customer' problems.