JAK-IN-1 NEW
| Price | $1820 | $2380 | $3100 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-08-21 |
Product Details
| Product Name: JAK-IN-1 | CAS No.: 1334673-53-8 |
| Supply Ability: 10g | Release date: 2025/08/21 |
Product Introduction
Bioactivity
| Name | JAK-IN-1 |
| Description | JAK-IN-1 shows improved selectivity for JAK3 over JAK1. JAK-IN-1 is a JAK1/2/3 inhibitor with IC50s of 0.26, 0.8 and 3.2 nM, respectively. |
| In vitro | JAK-IN-1 exhibits both mechanistic and functional activity in cell-based assays involving T-cells, a primary cell type where JAK3 has potential relevance. It effectively inhibits the proliferation of human CD4 and CD8 T cells in a dose-dependent fashion when stimulated by anti-CD3/anti-CD28 antibody-coated beads, which partially simulate the activation signals delivered to a T cell by an antigen-presenting cell. |
| In vivo | JAK-IN-1 effectively inhibits IL-2-induced STAT5 phosphorylation in both a dose- and concentration-dependent fashion, achieving roughly 50% reduction at a dose of 10 mg/kg (plasma concentration approximately 480 nM). Demonstrating selectivity for JAK3 in vivo, JAK-IN-1 exhibits greater efficacy in inhibiting JAK1/JAK3-driven signaling compared to pathways involving JAK2 or the combination of JAK1, JAK2, and TYK2, as evaluated through whole blood assays. Additionally, JAK-IN-1 strongly suppresses IL-2 stimulated plasma concentrations corresponding to each administered dose. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | JAK-IN-1 | JAKIN1 | JAK3 | JAK2 | JAK1 | JAK IN 1 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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