K-252a NEW
| Price | $99 |
| Package | 1mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-14 |
Product Details
| Product Name: K-252a | CAS No.: 99533-80-9 |
| Supply Ability: 10g | Release date: 2025/10/14 |
Product Introduction
Bioactivity
| Name | K-252a |
| Description | K-252a is a protein kinase inhibitor targeting serine-threonine, tyrosine, and CAM kinases. In vitro, it blocks NGF-induced TrkA signalling and neural differentiation, exhibiting antitumour, antibacterial, anti-inflammatory, and neuroprotective activities. |
| In vitro | Methods: LINC00641 overexpressing cell lines were treated with K-252a (1.7 nM, 6 hours), and the expression of target proteins in cells was detected by Western blotting. Results: K-252a can reduce the levels of p-Akt and p-TrkB in LINC00641 overexpressing cell lines. [3] Methods: PC12 subclone h cells were treated with K-252a (3-100 nM, 8 days) to study its effect on cell viability. Results: K-252a can inhibit NGF-induced neurite outgrowth. [4] |
| In vivo | Methods: Mice were treated with K-252a (20 mg/kg, intraperitoneal injection, once a day for 5 days) and their neurological function was evaluated. Results: K-252a was able to inhibit the TH-induced neuroprotective effect in mice. [5] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 40 mg/mL (85.57 mM), Sonication is recommended. |
| Keywords | SF-2370 | SF 2370 | PKC | PKA | phosphorylase kinase | K-252a | K252a | K 252a | Ca2+/calmodulin-dependent kinase type II | Antibiotic SF-2370 | Antibiotic SF2370 |
| Inhibitors Related | Neomycin sulfate | Aceglutamide | Cysteamine hydrochloride | Sulfamethoxazole sodium | Terbinafine hydrochloride | Hydroxychloroquine | Metronidazole | Doxycycline | Tributyrin | Paeonol | Alginic acid | Dextran sulfate sodium salt (MW 5000) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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