Product Details
| Product Name:
KP496 |
CAS No.:
217799-03-6 |
| Supply Ability:
10g |
Release date:
2025/10/27 |
Product Introduction
Bioactivity
| Name | KP496 |
| Description | KP496 is a selective, dual antagonist for the Thromboxane A2 receptor (TP) and the Leukotriene D4 receptor (cysLT1). |
| In vivo | KP496 and prednisolone markedly reduce the rise in hydroxyl-L-proline levels in the lung, showing an inhibition ratio of approximately 74% and 63%, respectively, when compared to their own vehicle control groups. Both compounds at doses of KP496 (100 mg/head) and prednisolone (10 mg/kg) significantly decrease the infiltration of total cells, including eosinophils, monocytes/macrophages, and lymphocytes, relative to the control group. Additionally, KP496 at a lower dose (30mg/head) reduces the infiltration of these cell types, except for neutrophils, albeit not significantly. Furthermore, KP496 effectively curtails both acute (day 7) and chronic (day 21) lung inflammation, reducing lymphocyte numbers by day 7 and counts of macrophages, neutrophils, and eosinophils on days 7 and 21. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | TXA2 Receptor | LTD4 | KP-496 | KP496 | KP 496 |
| Inhibitors Related | Montelukast sodium | Pranoprofen | Tranilast | Tetrahexyldecyl ascorbate | Rutin | Olsalazine disodium | Ozagrel | Amtolmetin guacil | Ethamsylate | Evodiamine | Lornoxicam | p-Hydroxycinnamic acid |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$1820.00/25mg |
VIP2Y
|
TargetMol Chemicals Inc.
|
2025-07-22 |
United States