KRN2 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-28 |
Product Details
| Product Name: KRN2 | CAS No.: 248260-75-5 |
| Supply Ability: 10g | Release date: 2025/10/28 |
Product Introduction
Bioactivity
| Name | KRN2 |
| Description | KRN2 has potential to treat NFAT5-mediated Chronic Arthritis. KRN2 is a selective inhibitor of nuclear factor of activated T cells (NFAT5), with an IC50 of 100 nM. |
| In vitro | KRN2 selectively and dose-dependently inhibits the binding of NF-κB p65 to the Nfat5 promoter 1 and impedes its interaction with the DNA binding sequence located in the upstream site (base pairs -3000 to +1) of Nfat5 exon 1. Moreover, KRN2 effectively suppresses the expression of pro-inflammatory genes such as Nos2 and Il6, while sparing the activation of high-salt-induced NFAT5 and related target gene expressions. |
| In vivo | KRN2 (3 mg/kg, i.p., daily) effectively suppresses CIA and AIA in mice by reducing pro-inflammatory cytokines, autoantibodies, and macrophage infiltration. Additionally, KRN2 (3 mg/kg, i.p., daily for 2 weeks) significantly suppresses AIA, where innate immune cells are predominantly involved. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | NFAT5 | KRN-2 | KRN2 | KRN 2 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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