Product Details
| Product Name:
Litronesib |
CAS No.:
910634-41-2 |
| Supply Ability:
10g |
Release date:
2025/10/27 |
Product Introduction
Bioactivity
| Name | Litronesib |
| Description | Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity. |
| In vitro | Litronesib (LY2523355) functions as a selective inhibitor of Eg5, promoting cancer cell death by inducing mitotic arrest at a concentration of 25 nM. This process requires the prolonged activation of the spindle-assembly checkpoint (SAC)[1]. |
| In vivo | Litronesib (LY2523355; 1.1, 3.3, 10, and 30 mg/kg, i.v.) displays antitumor activity in a dose-dependently. It also leads to a dramatic increase in cancer cells immuno-positive for histone H3 phosphorylation in Colo205 xenograft tumors[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 50 mg/mL (97.71 mM), Sonication is recommended.
|
| Keywords | LY2523355 | LY 2523355 | Litronesib | KF89617 | KF 89617 | Eg5 |
| Inhibitors Related | Eg5-IN-1 | Eg5 Inhibitor V, trans-24 | AZD-4877 | UMK57 | BAY1217389 | BRD9876 | Paprotrain | SB-743921 hydrochloride | S-trityl-L-Cysteine | Empesertib | MPI-0479605 | CW-069 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
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Suppliers |
Update time |
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$/ |
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States