LysRs-IN-2 NEW
| Price | $833 | $1130 | $1530 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-30 |
Product Details
| Product Name: LysRs-IN-2 | CAS No.: 2170696-76-9 |
| Purity: 99.34% | Supply Ability: 10g |
| Release date: 2025/04/30 |
Product Introduction
Bioactivity
| Name | LysRs-IN-2 |
| Description | LysRs-IN-2 is a lysine tRNA synthetase (KRS) inhibitor with antiparasitic activity that inhibits Plasmodium falciparum KRS (PfKRS) and Cryptosporidium minum KRS (CpKRS), and is used in the study of malaria infections. |
| In vitro | LysRs-IN-2 is a lysyl-tRNA synthetase (KRS) inhibitor with half inhibitory concentrations (IC50) of 0.015 μM and 0.13 μM for Plasmodium falciparum lysyl-tRNA synthetase (PfKRS) and Cryptosporidium lysyl-tRNA synthetase (CpKRS) respectively.[1] LysRs-IN-2 showed significant activity against P. falciparum strain 3D7 (EC50=0.27 μM), human lysyl-tRNA synthetase (HsKRS) (IC50=1.8 μM), HepG2 cells (EC50=49 μM), and Cryptosporidium minis (EC50=2.5 μM) in a whole-cell assay. [1] |
| In vivo | In the P. falciparum SCID mouse model, LysRs-IN-2 (1.5 mg/kg; orally once daily for 4 days) reduced parasitemia levels by 90%. In NOD SCID gamma mice and INF-γ knockout mice (Cryptosporidium minis model), LysRs-IN-2 (20 mg/kg; orally once daily for 7 days) significantly reduced parasite excretion. [1] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50.00 mg/mL (140.72 mM), Sonication is recommended. |
| Keywords | PfKRS | LysRs-IN-2 | LysRsIN2 | LysRs IN 2 | CpKRS |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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