Product Details
| Product Name:
M2698 |
CAS No.:
1379545-95-5 |
| Purity:
99.88% |
Supply Ability:
10g |
| Release date:
2025/11/09 |
Product Introduction
Bioactivity
| Name | M2698 |
| Description | M2698 (MSC2363318A) is an inhibitor of p70S6K, Akt1 and Akt3 with IC50s of 1 nM. M2698 shows anti-cancer activity. |
| In vitro | M2698 (0.3 nM-50 M) dose-dependently inhibits proliferation in breast tumor cell lines (IC50s: 0.02-8.5 µM). M2698 (0.3-1 µM) induces feedback loop phosphorylation on Akt and suppresses Akt and p70S6K activity in HCC1419 and MDA-MB-453 cells. M2698 inhibits indirectly pGSK3β and pS6 with IC50s of 17 and 15 nM[1]. |
| In vivo | Gavage administration of M2698 (10-30 mg/kg) dose-dependently inhibits the growth of tumors and increases pAkt levels in tumor tissue. M2698 (30 mg/kg) causes tumor regression. M2698 (1-20 mg/kg) inhibits S6 phosphorylation in a dose-proportional manner over time[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (8.89 mM), Sonication is recommended.
DMSO : 112.5 mg/mL (250.1 mM), Sonication is recommended.
|
| Keywords | p70S6K | M-2698 | M2698 | M 2698 | Akt3 | Akt1 |
| Inhibitors Related | Musk ketone | L-Leucine | 4-Methylbenzylidene camphor | Berberine hydrogen sulphate | Artemisinin | Afatinib | Chloramphenicol | Thymoquinone | 2,3-Butanediol | Dihydromyricetin | Berberine sulfate | Sodium salicylate |
| Related Compound Libraries | Anti-Colorectal Cancer Compound Library | Bioactive Compound Library | Kinase Inhibitor Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$43.00/1mg |
VIP4Y
|
TargetMol Chemicals Inc.
|
2025-11-10 |
|
|
$1.00/1KG |
VIP6Y
|
Career Henan Chemical Co
|
2019-12-25 |
United States