Product Details
| Product Name:
MC2590 |
CAS No.:
2284460-01-9 |
| Purity:
99.64% |
Supply Ability:
10g |
| Release date:
2025/11/09 |
Product Introduction
Bioactivity
| Name | MC2590 |
| Description | MC2590 is a potent and selective histone deacetylase (HDAC) inhibitor that inhibits HDAC1-3, -6, -8, and -10 activities, induces cell cycle arrest, and promotes apoptosis. |
| In vitro | MC2625/MC2590 (Compound 5e), over 72 hours, inhibits colorectal cancer cells HCT116 (IC50=0.07 μM), lung adenocarcinoma cells A549 (IC50=0.32 μM), and chronic myeloid leukemia cells K562 (IC50=0.05 μM) [1].At concentrations of 1 and 5 μM over 24 and 48 hours, MC2625/MC2590 induces G2/M cell cycle arrest [1].
At concentrations of 1 and 5 μM over 24 and 48 hours, MC2625/MC2590 induces excessive acetylation activity of H3K9/14, increases acetylated-α-tubulin levels, and significantly upregulates p21 protein [1].At concentrations of 1 and 5 μM over 48 hours, MC2625/MC2590 increases mRNA expression of p21, BAX, and BAK, downregulates cell cycle proteins D1 and BCL-2, and modulates pro-apoptotic and anti-apoptotic microRNAs to induce apoptosis [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | HDAC | Apoptosis |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Cysteamine hydrochloride | Sodium 4-phenylbutyrate | L-Ascorbic acid | L-Glutamic acid | Tributyrin | Valproic Acid | Curcumin | L-Ascorbic acid sodium salt | Alginic acid | Dextran sulfate sodium salt (MW 5000) |
| Related Compound Libraries | Apoptosis Compound Library | DNA Damage & Repair Compound Library | Reprogramming Compound Library | Histone Modification Compound Library | Bioactive Compound Library | Epigenetics Compound Library | HIF-1 Signaling Pathway Compound Library | Hematonosis Compound Library | Inhibitor Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States