Product Details
| Product Name:
MK-5046 |
CAS No.:
1022152-70-0 |
| Purity:
99.91% |
Supply Ability:
10g |
| Release date:
2025/11/04 |
Product Introduction
Bioactivity
| Name | MK-5046 |
| Description | MK-5046 is a novel BRS-3 agonist, binding to BRS-3 with high affinity (mouse Ki = 1.6 nM, human Ki = 25 nM). |
| Kinase Assay | Raf-MEK-ERK cascade kinase assay: Non-phosphorylated myelin basic protein (MBP) is coated onto an ELISA plate, and the active form of B-Raf/c-Raf is mixed with unphosphorylated MEK1/MEK2 and ERERK2 in 10 μM ATP and 12.5 mM MgCl2 containing MOPS buffer in the presence of various concentrations of GSK1120212. The phosphorylation of MBP is detected by the anti-phospho-MBP antibody. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (2.25 mM), Sonication is recommended.
DMSO : 10 mM, Sonication is recommended.
|
| Keywords | MK-5046 | MK5046 | MK 5046 | Inhibitor | inhibit | BRS-3 | BombesinReceptor | Bombesin Receptor |
| Inhibitors Related | [D-Phe12]-Bombesin acetate | BA 1 acetate(183241-31-8 free base) | [D-Phe12,Leu14]-Bombesin acetate | ML-18 | Bombesin acetate(31362-50-2 free base) | kuwanon G | Kuwanon H | CD80-IN-3 | Litorin acetate(55749-97-8 Free base) | PD176252 | PD 168368 | GRP (14-27) (human, porcine, canine) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$0.00/10g |
VIP1Y
|
Wuhan Kejiefeng Trading Co.,Ltd
|
2025-05-07 |
|
|
$0.00/1kg |
VIP2Y
|
Shaanxi Xianhe Biotech Co., Ltd
|
2025-04-14 |
|
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$0.00/1kg |
VIP2Y
|
Shandong Hanjiang Chemical Co., Ltd
|
2024-01-19 |
United States