Product Details
| Product Name:
ML218 |
CAS No.:
1346233-68-8 |
| Purity:
99.45% |
Supply Ability:
10g |
| Release date:
2025/12/04 |
Product Introduction
Bioactivity
| Name | ML218 |
| Description | ML218 is an orally active, selective, potent, and blood-brain barrier-crossing inhibitor of T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3) (IC50 for Cav3.2 and Cav3.3 is 310 nM and 270 nM, respectively).ML218 inhibits the burst activity of neurons in the subthalamic nucleus (STN). |
| In vitro | In a voltage clamp experiment, bath application of 3 μM ML218 significantly reduced the T-type Ca2+ current by ∼45%[1]. |
| In vivo | In Male Sprague-Dawley rats (275-299 g) induced by haloperidol,ML218 (0.03 mg/kg, 0.1 mg/kg, 0.3 mg/kg, 1 mg/kg, 3 mg/kg, 10 mg/kg, 30 mg/kg; Oral administration; once) treatment reversed cataleptic behavior in rats induced by a 0.75 mg/kg dose of haloperidol[1]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 100 mg/mL (270.76 mM), Sonication is recommended.
|
| Keywords | ML-218 | ML218 | ML 218 | Cav3.3 | Cav3.2 | CalciumChannel | Calcium Channel | Ca2+ flux |
| Inhibitors Related | Nisoldipine | Nimodipine | Levetiracetam | Cromolyn sodium | Levamlodipine besylate | Acetylcholine chloride | 1-Octanol | Amlodipine | Nifedipine | Dantrolene sodium hemiheptahydrate | Nicardipine hydrochloride | Nitrendipine |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States