MMAF Hydrochloride NEW
| Price | Get Latest Price | |
| Package | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-28 |
Product Details
| Product Name: MMAF Hydrochloride | CAS No.: 1415246-68-2 |
| Supply Ability: 10g | Release date: 2025/07/28 |
Product Introduction
Bioactivity
| Name | MMAF Hydrochloride |
| Description | MMAF Hydrochloride is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF Hydrochloride is an effective tubulin polymerization inhibitor and is used as an antitumor compound. |
| In vitro | MMAF suppresses anaplastic large cell lymphoma Karpas 299, breast carcinoma H3396, renal cell carcinoma 786-O, and Caki-1 cells. It has IC50s of 119, 105, 257, and 200 nM in vitro cytotoxicity assay[4]. |
| In vivo | cAC10-L1-MMAF4 has an MTD of 50 mg/kg in mice and 15 mg/kg in rats, whereas the cAC10-L4-MMAF4 ADC is much less toxic, with MTDs of >150 mg/kg in mice and 90 mg/kg in rats. The maximum tolerated dose of MMAF (>16 mg/kg) in mice is much higher than that of MMAE (1 mg/kg) [4]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 27 mg/mL (35.14 mM), Sonication and heating are recommended. |
| Keywords | MMAF Hydrochloride | Auristatin | ADCCytotoxin | ADC Cytotoxin |
| Inhibitors Related | Methotrexate | Mertansine | Doxorubicin hydrochloride | Daunorubicin hydrochloride | Exatecan | Methotrexate disodium | Camptothecin | Dexamethasone | Fluticasone (propionate) | Paclitaxel | 17-AEP-GA | Exatecan Mesylate |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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