Monophosphoryl lipid A NEW
| Price | $1110 |
| Package | 1mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-08-21 |
Product Details
| Product Name: Monophosphoryl lipid A | CAS No.: 1246298-63-4 |
| Supply Ability: 10g | Release date: 2025/08/21 |
Product Introduction
Bioactivity
| Name | Monophosphoryl lipid A |
| Description | Monophosphoryl lipid A (MPLA), also known as Glucopyranosyl lipid A, is an agonist of toll-like receptor 4. Derived from the cell wall of nonpathogenic Salmonella, MPLA is a valuable compound for research on immunization and vaccine development. |
| In vitro | Monophosphoryl lipid A, at a concentration of 100 µg/ml for 2 hours, induces NF-κB activation and modulates TLR2 in dendritic cells, as evidenced by Western Blot Analysis. The same compound, ranging from 5 to 100 µg/ml over 24 hours, stimulates IL-12 production in human dendritic cells. Furthermore, increasing Monophosphoryl lipid A levels from 0.1 to 1 µg results in a higher percentage of matured bone marrow-derived dendritic cells (BMDCs). It also enhances cell surface markers on dendritic cells and boosts T cell responses, including the upregulation of calcium mobilization in activated CD4 T cells. |
| In vivo | The synthesized Monophosphoryl lipid A activates antigen-presenting cells (APCs) and amplifies the production of Th1- and Th2-specific immune responses in mice[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Monophosphoryl lipid A |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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