Morinidazole Impurity 42(Bromide) NEW

Morinidazole Impurity 42(Bromide)

WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com.

• Product Information

• Product Number: M035042A

• English Name: Morinidazole Impurity 42(Bromide)

• English Alias: 1-ethyl-1-(2-hydroxy-3-morpholinopropyl)-2-methyl-5-nitro-1H-imidazol-1-ium bromide

• CAS Number: None

• Molecular Formula: C₁₃H₂₃N₄O₄·Br

• Molecular Weight: 379.25（299.35 + 79.90）

• Advantages

• As an impurity reference standard (bromide form) for morinidazole, this compound has the following advantages:
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• With a well-defined structure and stable salt form, it can be precisely used to analyze the by-product formation mechanism of alkylation, nitration, and salification reactions during morinidazole synthesis, providing a basis for optimizing the production process.

• Containing multiple functional groups such as imidazole ring, morpholine group, and nitro group, it can serve as a standard substance, significantly improving the separation and quantification accuracy of detection methods such as HPLC and LC-MS for impurities related to morinidazole.

• The bromide form enhances the water solubility of the compound, facilitating the simulation of impurity behavior in physiological environments during formulation stability studies and impurity detection.

• Applications

• Drug Development: During the research and development of morinidazole and its formulations, it is used as an impurity reference standard to identify and quantitatively analyze Morinidazole Impurity 42(Bromide), accurately evaluating the purity of APIs and formulations.

• Quality Control: As a standard substance, it is used to verify the sensitivity and specificity of detection methods such as HPLC and LC-MS, strictly ensuring that the content of this impurity during production meets pharmacopoeia and relevant regulatory requirements.

• Stability Studies: Investigating the degradation behavior of this impurity under different environmental conditions such as light, high temperature, and high humidity, evaluating its impact on the stability of morinidazole formulations, and providing data support for formulating reasonable storage conditions and shelf life.

• Background Description

• Morinidazole is a nitroimidazole antibacterial drug commonly used in the treatment of anaerobic infections. During its synthesis, due to the complex reaction steps involving multiple functional group transformations and structural modifications, if reaction conditions are not properly controlled or raw materials remain, impurities such as 1-ethyl-1-(2-hydroxy-3-morpholinopropyl)-2-methyl-5-nitro-1H-imidazol-1-ium bromide are likely to be generated. The presence of such impurities may affect the safety, effectiveness, and bioavailability of the drug. Therefore, the research and control of morinidazole impurities are key links in ensuring drug quality.

• Research Status

• Currently, research on Morinidazole Impurity 42(Bromide) mainly focuses on the following aspects:
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• Detection Method Optimization: Using advanced technologies such as ultra-high-performance liquid chromatography - tandem mass spectrometry (UPLC-MS/MS) and high-resolution mass spectrometry (HRMS) to develop highly sensitive and selective detection methods for trace detection of this impurity.

• Synthesis Process Improvement: Deeply studying the formation pathway of this impurity, and developing synthesis processes that reduce impurity generation by optimizing reaction conditions (such as reaction temperature, time, catalyst selection) and raw material ratios.

• Toxicological Evaluation: Evaluating the potential toxicity of this impurity through in vitro cytotoxicity experiments and animal models, providing data support for scientifically formulating reasonable impurity limit standards.

• Stability Studies: Systematically studying the stability of this impurity under the influence of different environmental factors, analyzing its impact on the quality of morinidazole formulations, and further improving the drug quality control system

This product is intended for laboratory use only!

WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com