MRK-623 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-27 |
Product Details
| Product Name: MRK-623 | CAS No.: 461449-78-5 |
| Supply Ability: 10g | Release date: 2025/10/27 |
Product Introduction
Bioactivity
| Name | MRK-623 |
| Description | MRK-623 (Compound 14k) is a potent, orally active agonist of the GABA A receptor with high affinity for subunits α1, α2, α3, and α5, exhibiting Ki values of 0.85 nM, 3.7 nM, 4.0 nM, and 0.53 nM, respectively. Notably, MRK-623 demonstrates anxiolytic effects [1]. |
| In vitro | MRK-623 demonstrates effectiveness on human GABAA receptor subtypes, which are expressed in L(tk-) cells. This has been measured using whole cell patch-clamp electrophysiology [1]. |
| In vivo | MRK-623, administered via oral gavage at dosages of 0.3, 1, and 3 mg/kg on a single occasion, demonstrates anxiolytic effects in rats as measured by the elevated plus maze assay [1]. Specifically, at a dosage of 3 mg/kg, MRK-623 achieved 78% benzodiazepine (BZ) site occupancy, with an inhibitory dose 50 (ID 50) identified at 0.8 mg/kg. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Inhibitors Related | Compound PDK0243 | p-Hydroxybenzaldehyde | Urethane | Baicalin | Penicillin G sodium salt | DL-Pyroglutamic acid | Valproic Acid | Halothane | Chlorothymol | (-)-α-Pinene | Dihydromyricetin | Methionine |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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