Norbinaltorphimine dihydrochloride NEW
| Price | $32 | $77 |
| Package | 1mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-11-10 |
Product Details
| Product Name: Norbinaltorphimine dihydrochloride | CAS No.: 113158-34-2 |
| Purity: 99.88% | Supply Ability: 10g |
| Release date: 2025/11/10 |
Product Introduction
Bioactivity
| Name | Norbinaltorphimine dihydrochloride |
| Description | Norbinaltorphimine dihydrochloride is a selective and potent κ opioid receptor antagonist that induces itch-associated responses in mice. |
| In vitro | Norbinaltorphimine dihydrochloride reversibly antagonizes the effects of κ agonists with pA2 values ranging from 10.2 to 10.4. However, it is important to note that Norbinaltorphimine dihydrochloride is much less potent as an antagonist at μ and δ receptors, where the pA2 values are 7.4-7.6 and 7.6-7.8, respectively[3]. |
| In vivo | In adolescent rats, Norbinaltorphimine dihydrochloride exhibits weak and inconsistent effects on THC-induced taste avoidance. Notably, the impact of Norbinaltorphimine dihydrochloride varies based on dose and trial, as it both attenuates and strengthens taste avoidance. However, these effects are limited, with no significant influence on the final one-bottle avoidance and no observable effects on the two-bottle preference test. Interestingly, Norbinaltorphimine dihydrochloride demonstrates no effect on THC-induced taste avoidance in adult rats as well[2].Furthermore, when administered as a pretreatment,Norbinaltorphimine dihydrochloride significantly attenuates stress-induced reinstatement of nicotine-conditioned place preference (CPP). However, it is important to note that Norbinaltorphimine dihydrochloride has no discernible effect on nicotine-primed reinstatement[1]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (108.89 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (4.49 mM), Sonication is recommended. H2O : 20 mg/mL (27.22 mM), Sonication is recommended. |
| Keywords | κ opioid receptor | OpioidReceptor | Opioid Receptor | nor-BNI Dihydrochloride | nor-BNI | nor-Binaltorphimine Dihydrochloride | Norbinaltorphimine dihydrochloride | Norbinaltorphimine Dihydrochloride | nor-Binaltorphimine | Norbinaltorphimine |
| Inhibitors Related | Docusate sodium | Bevenopran | Mirtazapine | (-)-Menthol | SCH 221510 | Naltrexone hydrochloride | Progesterone | Meptazinol hydrochloride | Trimebutine | Mianserin hydrochloride | Amentoflavone | Trimebutine maleate |
| Related Compound Libraries | Bioactive Compound Library | Pain-Related Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Inhibitor Library | Bioactive Compounds Library Max | GPCR Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $2500.00/100mg |
VIP2Y
|
TargetMol Chemicals Inc.
|
2025-04-29 | |
| $1.00/1kg |
VIP5Y
|
RongNa Biotechnology Co.,Ltd
|
2024-03-26 | |
| $0.00/1kg |
VIP2Y
|
Anhuyan (Hainan) Biotechnology Co., LTD
|
2025-06-10 | |
| $77.00/5mg |
VIP6Y
|
TargetMol Chemicals Inc.
|
2025-11-10 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
INQUIRY