Norverapamil hydrochloride NEW
| Price | $113 | $197 | $332 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-12-05 |
Product Details
| Product Name: Norverapamil hydrochloride | CAS No.: 67812-42-4 |
| Purity: 99.63% | Supply Ability: 10g |
| Release date: 2025/12/05 |
Product Introduction
Bioactivity
| Name | Norverapamil hydrochloride |
| Description | Norverapamil hydrochloride (D591 hydrochloride) ((±)-Norverapamil hydrochloride) is an N-demethylated metabolite of Verapamil and it is an L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor. |
| In vitro | Norverapamil inhibits macrophage-induced tolerance and attains serum levels comparable to verapamil. Both verapamil and its primary metabolite, Norverapamil, are identified as mechanism-based inhibitors and substrates of CYP3A, exhibiting non-linear pharmacokinetics clinically. Furthermore, ((±)-Norverapamil hydrochloride) proves as effective as verapamil in inhibiting tolerance and killing intracellular M. tuberculosis in monotherapy, matching its efficacy against isoniazid and rifampicin tolerance [1][3]. |
| In vivo | Norverapamil hydrochloride (9 mg/kg; p.o.) exhibits a terminal half-life of 9.4 hours, an AUC of 260 ng ml−1 h, and a Cmax of 41.6 ng/mL[4]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (4.19 mM), Sonication is recommended. H2O : 50 mg/mL (104.81 mM), Sonication is recommended. DMSO : 31 mg/mL (64.98 mM), Sonication is recommended. |
| Keywords | pumps | P-gp (P-glycoprotein) | P-gp | Pgp | P-glycoprotein (P-gp) inhibitor | P-glycoprotein | Norverapamil Hydrochloride | Norverapamil hydrochloride | Norverapamil | mycobacterial | Multidrug resistance protein 1 | metabolite | MDR1 | M. tuberculosis | Inhibitor | inhibit | efflux | DrugMetabolite | Drug Metabolite | D-591 Hydrochloride | D591 Hydrochloride | D-591 | D591 | D 591 Hydrochloride | D 591 | Cluster of differentiation 243 | CD243 | CalciumChannel | Calcium channel blocker | Calcium Channel | Calcium channel | Ca2+ channels | Ca channels | ABCB1 | (±)-Norverapamil |
| Inhibitors Related | Quadrol | 2,4,6-Tri-tert-butylphenol | Melamine | Mycophenolate Mofetil | L-Ascorbic acid | 10-Undecen-1-ol | Isonicotinic acid | L-Ascorbic acid sodium salt | 2-Nitrobenzoic acid | Magnesium Chloride Hexahydrate | Lansoprazole sulfide | Magnesium sulfate |
| Related Compound Libraries | Bioactive Compound Library | Pain-Related Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Neuroprotective Compound Library | Inhibitor Library | NO PAINS Compound Library | Anti-Cardiovascular Disease Compound Library | Bioactive Compounds Library Max | Drug Metabolite/Impurity Library | Ion Channel Targeted Library | Anti-Hypertension Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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