Notoginsenoside Ft1 NEW

product introduce:

Use of Notoginsenoside Ft1

Notoginsenoside Ft1 is a saponin isolated from Panax notoginseng; stimulator of angiogenesis.IC50 value:Target: angiogenesis stimulatorin vitro: Ft1 increases translocalization of hypoxia-inducible factor-1α (HIF-1α) from cytoplasm to nuclei, where it binds to the vascular endothelial growth factor (VEGF) promoter, increasing the expression of VEGF mRNA and the subsequent secretion of the growth factor. Ft1 induces the activation of PI3K/AKT and Raf/MEK/ERK signaling pathways [1]. Among the saponins examined, Ft1 was the most potent procoagulant and induced dose-dependent platelet aggregation. Ft1 reduced plasma coagulation indexes, decreased tail bleeding time and increased thrombogenesis. Moreover, it potentiated ADP-induced platelet aggregation and increased cytosolic Ca(2+) accumulation, effects that were attenuated by clopidogrel. Ft1 binds to platelet P2Y12 receptors. The increase in intracellular Ca(2+) evoked by Ft1 in HEK293 cells overexpressing P2Y12 receptors could be blocked by ticagrelor [2]. Ft1 caused endothelium-dependent relaxations, which were abolished by l-NAME (inhibitor of nitric oxide synthases) and ODQ (inhibitor of soluble guanylyl cyclase). Ft1 increased the cGMP level in rat mesenteric arteries. GR and ER? were present in the endothelial layer and their antagonism by RU486 and PHTPP, respectively, inhibited Ft1-induced endothelium-dependent relaxations and phosphorylations of eNOS, Akt and ERK1/2 [3]. Ft1 showed the best inhibitory effect on cell proliferation of SH-SY5Y cells with IC50 of 45μM. Ft1 not only arrested the cell cycle at S, G2/M stages, but also promoted cell apoptosis. Ft1 up-regulated the protein expressions of cleaved caspase 3, phospho-p53, p21, and cyclin B1, but down-regulated that of Bcl-2. Moreover, Ft1 enhanced the phosphorylation of ERK1/2, JNK and p38 MAPK [4].in vivo: Ft1 promotes the formation of blood vessels in Matrigel plug and wound healing in mice

Packing,StorageTransportation:
1. Packing: 25 kg/bag

2. Storage: Store in a dry and ventilated place, and pay attention to moisture and humidity. Long-term storage does not deteriorate, if there is caking, crushing or dissolution does not affect the use effect.

3. Transportation: This product is non-toxic and harmless, non-flammable and explosive dangerous goods. It can be transported by car, sea or train. Less carload, vehicle is not limited, agent consignment.

Transport:
1.Transit could be DHL,UPS,TNT,EMS,Fedex,and so on.
2.For mass orders, it will be delivered by air or sea.
3.Depending on your location, please allow 1-5 business days for your order to arrive.
4.For small order, please expect 3-7 days by UPS DHL EMS.
5.For mass order, please allow 5-8 days by Air, 15-30 days by Sea.
Company Profile:
  We are Ouhuang Engineering Materials (Hubei) Co., Ltd.Our company mainly produces and sells various Building materials materials and various production AIDS water-based environmentally friendly resins (water-based resin powder, water-based rosin resin, water-based terpene tree, etc.), various water-based environmentally friendly latex (water-based thickened emulsion, water-based air-butyl latex, water-based butyl latex, etc.) , and various environmentally friendly additives (defoamer, thickener, antioxidant, dispersant).High-end product quality and sincere sales service are our tenets.We are willing to provide you with professional services in the areas we are familiar with and look forward to your consultation.  
Our advantage:
1.Our company has a professional research team to develop building raw materials chemical products and mature technicians to create value
2.We can also meet the special customization needs of customers as well as various special packaging requirements.
3.We can also provide samples to our customers free of charge.
4.We provide commercial invoice, packing list, Bill of Lading, COA, Health Certificate and Certificate of Origin. If your market has any special requirements, please let us know.
5.Prompt delivery, as long as you confirm that the order is available in stock can be arranged within 24h.
6.Diversification of payment methods,Such as L/C, T/T, D/A, D/P, paypal, Western Union etc, and we cooperate with Sinosure many years.
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