Product Details
| Product Name:
OSMI-2 |
CAS No.:
2260542-60-5 |
| Supply Ability:
10g |
Release date:
2025/10/27 |
Product Introduction
Bioactivity
| Name | OSMI-2 |
| Description | OSMI-2 is a cell-permeable inhibitor of O-linked N-acetylglucosamine transferase (OGT). |
| In vitro | In ?HCT116 cells,OSMI-2 ?treatment reduces O-GlcNAc levels at short treatment times (<8h).?However, O-GlcNAc levels begins to recover at longer treatment times with OSMI-2.?A decrease in HCF-1 cleavage products and the appearance of uncleaved HCF-1 in cells treated with OSMI-2 ?is observed.?Because OGT knockdown is known to decrease cell proliferation, the effects of OSMI-2 on cell growth in culture over 96h is also monitored.?Although there is no evidence of apoptosis, the reduced growth of cells over time is observed, consistent with the knockdown results.?A time course performed with 20 μM OSMI-2 shows reciprocal changes in the abundance of OGT and OGA, with a particularly large increase in OGT;?this may explain the recovery in O-GlcNAc levels with OSMI-2.?At 24h where O-GlcNAc levels fully recovered[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | OSMI2 | OSMI 2 | OSMI-2 |
| Inhibitors Related | Alendronate sodium trihydrate | Xanthohumol | Serotonin hydrochloride | Rosmarinic acid | Cyclandelate | Risedronic Acid | Entacapone | CBHcy | 2-Furoic acid | OU749 | Ibandronate sodium | Flopropione |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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