p-Cresyl sulfate NEW
| Price | $51 | $122 | $197 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-11-05 |
Product Details
| Product Name: p-Cresyl sulfate | CAS No.: 3233-58-7 |
| Purity: 99.46% | Supply Ability: 10g |
| Release date: 2025/11/05 |
Product Introduction
Bioactivity
| Name | p-Cresyl sulfate |
| Description | p-Cresyl Sulfate is the major uremic toxin present in the blood of patients with chronic kidney disease and is derived from the metabolites of tyrosine and phenylalanine in the liver. |
| In vitro | METHODS: H9C2 cardiomyocytes were treated with p-Cresyl Sulfate (3.125, 6.25, 12.5, 25.0 μg/mL) to study the changes in cell proliferation, cell size and mitochondrial parameters, including morphology, respiration, biogenesis and membrane potential. RESULTS The lowest effective dose of p-Cresyl Sulfate (6.25 μg/mL) induced mitochondrial hypertransfusion, enhanced mitochondrial connectivity, increased mitochondrial oxygen consumption rate, mitochondrial mass, mitochondrial DNA copy number and cardiomyocyte volume; at the same time, p-Cresyl Sulfate increased the phosphorylation of energy-sensing adenosine monophosphate-activated protein kinase (AMPK), but did not induce cell apoptosis. [2] |
| In vivo | METHODS: Mice with AKI induced by ischemia and reperfusion (IR) injury were treated with p-Cresyl Sulfate (20, 40, or 60 mg/L/day for 15 days) to evaluate the effects of p-Cresyl Sulfate administration on renal and cardiac function. RESULTS p-Cresyl Sulfate at a dose of 20 mg/L resulted in decreased renal mass, increased cystatin C and kidney injury molecule 1 (KIM-1) gene expression, and decreased α-actin in the heart. [3] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (26.57 mM), Sonication is recommended. DMSO : 250 mg/mL (1328.37 mM), Sonication is recommended. H2O : 100 mg/mL (531.35 mM), Sonication is recommended. |
| Keywords | p-Tolyl | p-Cresyl Sulfate | pCresyl sulfate | p-Cresyl | p Cresyl sulfate | Inhibitor | inhibit | Endogenous Metabolite |
| Inhibitors Related | Sucrose | Aceglutamide | Emtricitabine | 3-Hydroxybutyric acid sodium | Levulinic acid | D(+)-Raffinose pentahydrate | D-(+)-Trehalose dihydrate | Glycerol | Thymidine | Sodium 2-hydroxybutanoate | Chitosan oligosaccharide | 3-Indoleacetic acid |
| Related Compound Libraries | Bioactive Compound Library | Natural Product Library | NO PAINS Compound Library | Anti-Cardiovascular Disease Compound Library | Natural Product Library for HTS | Human Endogenous Metabolite Compound Library Plus | Bioactive Compounds Library Max | Gut Microbial Metabolite Library | Human Metabolite Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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