Product Details
| Product Name:
Patamostat |
CAS No.:
114568-26-2 |
| Supply Ability:
10g |
Release date:
2025/10/27 |
Product Introduction
Bioactivity
| Name | Patamostat |
| Description | Patamostat (E-3123) is a potent protease inhibitor that effectively inhibits trypsin, plasmin, and thrombin with IC50 values of 39 nM, 950 nM, and 1.9 µM, respectively. Research suggests it might suppress the pathogenesis and development of acute pancreatitis [1] [2]. |
| In vivo | Patamostat, administered through intravenous infusion, demonstrates dose-dependent efficacy in reducing mortality in rats (0.03-0.3 mg/kg) and rabbits (0.3-3.0 mg/kg) following pancreatitis induction. In dogs afflicted with pancreatitis, patamostat in doses ranging from 1.0 to 3.0 mg/kg mitigates the elevation of serum trypsin and lipase levels. A specific study with male Wistar rats, using a continuous infusion of 2 mg/kg per hour of patamostat, showcases significant improvements across multiple parameters. These include a reduction in mortality rate, serum and ascitic fluid amylase levels, plasma endotoxin and serum Fibrin Degradation Products (FDP) levels, and normalized distribution of lysosomal enzyme. This study involved male Wistar rats, averaging a weight of about 350 g, with the dosage administered continuously per hour for 1 h, resulting in notably enhanced survival rates. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Patamostat |
| Inhibitors Related | Trypsin Inhibitor, soybean | Nafamostat mesylate | Lodelaben | AEBSF hydrochloride | Imidazole | p-Aminobenzamidine dihydrochloride | Ceritinib | Proteinase K | Trypsin | FOY 251 | 2,4-Dioxaspiro(5.5)undec-8-ene, 3-(2-furanyl)- | Benzamidine hydrochloride |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$397.00/1mg |
VIP6Y
|
TargetMol Chemicals Inc.
|
2025-11-11 |
United States