Product Details
| Product Name:
PBRM |
CAS No.:
1318265-18-7 |
| Purity:
99.56% |
Supply Ability:
10g |
| Release date:
2025/04/27 |
Product Introduction
Bioactivity
| Name | PBRM |
| Description | PBRM (17β-HSD1-IN-2) is a selective covalent inhibitor of 17β-HSD1, used in breast cancer and endometriosis research. |
| In vitro | PBRM (0.1-10 μM) inhibited the formation of 5-diol from DHEA by T-47D cells in a dose-dependent manner with IC50 = 0.77 μM. [1] |
| In vivo | PBRM (15 mg/kg orally) effectively reversed T-47D tumor growth. [1]
The half-life of PBRM (14.7 mg/kg subcutaneous injection) in mice was T1/2= 3.4 hours, clearance CL = 2088 mL/h kg, distribution volume Vz = 10.3 L/kg, absolute bioavailability F = 65%. [2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | PBRM | DAU5884 | DAU 5884 HCl |
| Inhibitors Related | Sucrose | Acetaminophen | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | L-Methionine | Formamide | Glycerol | Thymidine | Naringin | 3-Indoleacetic acid |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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