PF-06424439 methanesulfonate NEW
| Price | $39 | $55 | $97 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-12 |
Product Details
| Product Name: PF-06424439 methanesulfonate | CAS No.: 1469284-79-4 |
| Purity: 99.77% | Supply Ability: 10g |
| Release date: 2025/05/12 |
Product Introduction
Bioactivity
| Name | PF-06424439 methanesulfonate |
| Description | PF-06424439 methanesulfonate, an orally administered, potent, and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 of 14 nM, demonstrates slow reversibility and time-dependent inhibition. It operates in a noncompetitive manner relative to the acyl-CoA substrate, marking its efficacy in targeting DGAT2. |
| Animal Research | PF-06424439 methanesulfonate (i.v.; 1 mg/kg) shows moderate clearance in rats following intravenous administration and moderate steady-state volume of distribution (Vdss) results in a short half-life[1].PF-06424439 methanesulfonate (p.o.; 60 mg/kg/day; for 3 days) reduces plasma TG and cholesterol levels and decreases nonsignificant in circulating lipids in mice (Ldlr-/-)[1]. |
| In vivo | PF-06424439 methanesulfonate shows moderate clearance in rats following intravenous administration and moderate steady-state volume of distribution (Vdss) results in a short half-life[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 249 mg/mL (464.50 mM), Sonication is recommended. H2O : 99 mg/mL (184.68 mM), Sonication is recommended. |
| Keywords | PF-06424439 methanesulfonate | PF06424439 methanesulfonate | PF-06424439 | PF06424439 | PF 06424439 methanesulfonate | PF 06424439 | mono- acylglycerol acyltransferase | Inhibitor | inhibit | Diglyceride acyltransferase | Diacylglycerol acyltransferase | DGAT2 | Acyltransferase | acyl-CoA:cholesterol acyltransferase |
| Inhibitors Related | Alendronate sodium trihydrate | Serotonin hydrochloride | Rosmarinic acid | Risedronate Sodium | Cyclandelate | Risedronic Acid | YM17E | Entacapone | 2-Furoic acid | OU749 | Ibandronate sodium | Flopropione |
| Related Compound Libraries | Bioactive Compound Library | Anti-Obesity Compound Library | Inhibitor Library | NO PAINS Compound Library | Metabolism Compound Library | Orally Active Compound Library | Lipid Metabolism Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $2800.00/100mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-10-28 | |
| $0.00/1kg |
VIP3Y
|
Henan Aochuang Chemical Co.,Ltd.
|
2022-10-14 | |
| $39.00/1mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2025-05-12 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
INQUIRY