PKR activator 1 NEW
| Price | $1520 |
| Package | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-27 |
Product Details
| Product Name: PKR activator 1 | CAS No.: 2283420-62-0 |
| Supply Ability: 10g | Release date: 2025/10/27 |
Product Introduction
Bioactivity
| Name | PKR activator 1 |
| Description | PKR activator 1 is a potent activator of pyruvate kinase-R (PKR). |
| In vitro | Four isoforms of Pyruvate kinase (PK) are found in mammals: L and R isoforms, produced by the PKLR gene, are expressed in the liver and red blood cells, respectively. The PKM gene is responsible for two splice variants: M1, prevalent in most adult tissues, and M2, found during embryonic development and in specific adult tissues, such as the kidney and hematopoietic stem cells. Additionally, many tumor cells express PKM2. This tetrameric isoform, which is allosterically regulated, is naturally predisposed to suppress its activity through several mechanisms: post-translational modifications, allosteric alterations by small molecules including certain amino acids, and conversion into a dimeric form. These processes lead to a partial blockade of glycolysis at its final stage[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | PKR activator 1 |
| Inhibitors Related | DL-Serine | PKM2-IN-1 | PKR-IN-2 | Disodium monofluorophosphate | Mitapivat | (+)-Shikonin | PKM2 inhibitor G | DASA-58 | Dimethylaminomicheliolide HCl | TEPP-46 | Mitapivat sulfate hydrate | PKM2 activator 2 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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