Praeruptorin B NEW
| Price | Get Latest Price |
| Package | 1removed |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-11-11 |
Product Details
| Product Name: Praeruptorin B | CAS No.: 73069-28-0 |
| Supply Ability: 10g | Release date: 2025/11/11 |
Product Introduction
Bioactivity
| Name | Praeruptorin B |
| Description | Praeruptorin B (Praeruptorin D), a compound found in the roots of Peuced, is an inhibitor of sterol regulatory element-binding proteins (SREBPs) that attenuates the metastatic ability of human renal cancer cells by targeting CTSC and CTSV expression, and can be used in the study of osteoporosis. |
| In vitro | Praeruptorin B inhibited the activity of SREBPs and reduced intracellular lipid levels, and significantly down-regulated the expression of SREBP-1c and SREBP-2.Praeruptorin B potently reduced SRE-luciferase activity and the effect was dose-dependent.[1] |
| In vivo | Mice treated with 50 mg/kg Praeruptorin B weighed significantly less than those treated with the vector, although they were still heavier than mice fed regular chow, suggesting that Praeruptorin B ameliorates diet-induced obesity (DIO). Staining results showed that Praeruptorin B-treated mice exhibited less lipid accumulation than vector-treated mice. Elevated fasting blood glucose and insulin levels in high-fat diet-fed mice were significantly reduced by Praeruptorin B. The results showed that the elevated fasting blood glucose and insulin levels in Praeruptorin B-treated mice were significantly reduced. [1] |
| Storage | keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 20 mg/mL(46.90 mM), Sonication is recommended. |
| Keywords | SREBPs | Praeruptorin B | Inhibitor | inhibit | Fatty Acid Synthase (FASN) |
| Inhibitors Related | HpFabZ Inhibitor 1 | 2-Octanone | Betulin | Denifanstat | Ezetimibe | Coenzyme A | A-769662 | Pyrazinamide | Orlistat | trans-Chalcone | TVB-3664 | L-Carnitine |
| Related Compound Libraries | Natural Product Library for HTS | Lipid Metabolism Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Address: 36 Washington Street, Wellesley Hill, MA
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