Pregnenolone monosulfate sodium NEW
| Price | Get Latest Price |
| Package | 1removed |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-12-05 |
Product Details
| Product Name: Pregnenolone monosulfate sodium | CAS No.: 1852-38-6 |
| Purity: 99.76% | Supply Ability: 10g |
| Release date: 2025/12/05 |
Product Introduction
Bioactivity
| Name | Pregnenolone monosulfate sodium |
| Description | Pregnenolone monosulfate sodium salt is the sodium salt form of Pregnenolone monosulfate.Pregnenolone monosulfate is an endogenous neurosteroid, enhances NMDA receptor-mediated synaptic activity and intracellular Ca²⁺ concentrations, activates CREB phosphorylation, activates TRPM3 channels, and may inhibit GABA A receptors. |
| In vitro | Pregnenolone monosulfate sodium does not alter agonist binding, but only agonist efficacy. Pregnenolone monosulfate sodium may act as a signal-specific negative allosteric modulator that occupies a site distinct from that occupied by the orthosteric ligand. When slices were pretreated with 100 nM Pregnenolone monosulfate sodium, the effects of THC were significantly attenuated (15.1 ± 1.8% inhibition). These effects may be due to Pregnenolone monosulfate sodium's presynaptic actions. Thus, Pregnenolone monosulfate sodium prevented the THC-induced increase in paired-pulse ratio but did not alter the amplitude or decay time of miniature EPSCs. [1] |
| In vivo | Pregnenolone monosulfate sodium (2, 4 mg/kg) injected before each dose reduced WIN 55,212-2 intake and lowered breakpoints in a progressive ratio schedule. Pregnenolone monosulfate sodium (2-6 mg/kg) blocked THC-induced food intake in Wistar rats and C57BL/6N mice and attenuated THC-induced memory impairment in mice, but it did not modify these behaviors by itself [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (191.15 mM), Sonication is recommended. H2O : 2 mg/mL (4.78 mM), Sonication is recommended. |
| Keywords | Pregnenolone monosulfate sodium salt | Pregnenolone monosulfate sodium | Human Endogenous Metabolite | CB1 | 3β-Hydroxy-5-pregnen-20-one monosulfate sodium salt | 3b-Hydroxy-5-pregnen-20-one monosulfate sodium | 3beta-Hydroxy-5-pregnen-20-one monosulfate sodium |
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| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Epigenetics Compound Library | Neurotransmitter Receptor Compound Library | Multi-Target Compound Library | Bioactive Compounds Library Max | Bioactive Lipid Compound Library | GPCR Compound Library | Ion Channel Targeted Library | Anti-Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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