Propargyl-PEG2-amine NEW
| Price | Get Latest Price |
| Package | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-27 |
Product Details
| Product Name: Propargyl-PEG2-amine | CAS No.: 944561-44-8 |
| Supply Ability: 10g | Release date: 2025/10/27 |
Product Introduction
Bioactivity
| Name | Propargyl-PEG2-amine |
| Description | Propargyl-PEG2-amine, a non-cleavable ADC linker, is used in the synthesis of antibody-drug conjugates (ADCs) and serves as a PEG-based PROTAC linker for PROTAC synthesis [1][2]. |
| In vitro | ADCs, or antibody-drug conjugates, consist of an antibody that is linked to a cytotoxic drug molecule via a specialized linker. This allows the antibody to specifically target certain cells or proteins, while the attached cytotoxin can selectively destroy those targeted cells. PROTACs, or proteolysis-targeting chimeras, are composed of two distinct ligands joined by a linker. One of these ligands binds to a specific protein target, while the other binds to an E3 ubiquitin ligase. When the PROTAC binds to both the target protein and the E4 ligase, it triggers the ubiquitin-proteasome system within cells to degrade the target protein, thereby providing a mechanism for targeted protein degradation. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Propargyl-PEG2-amine | Propargyl-PEG-2-amine | PropargylPEG2amine | Propargyl PEG2 amine | PEGs | Non-cleavable | ADCLinker | ADC Linker |
| Inhibitors Related | N-(4-Carboxycyclohexylmethyl)maleimide | Boc-C16-COOH | Azido-PEG1 | Succinic anhydride | Diethylene glycol bis(p-toluenesulfonate) | 6-Maleimidocapronic acid | Triethylene glycol | 11-Aminoundecanoic acid | 1,3-Dibromo-5,5-dimethylhydantoin | N-Hydroxysulfosuccinimide sodium | m-PEG12-NHS ester | Tetraethylene glycol |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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