PSI-697 NEW
| Price | $962 |
| Package | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-12-12 |
Product Details
| Product Name: PSI-697 | CAS No.: 851546-61-7 |
| Purity: 98.97% | Supply Ability: 10g |
| Release date: 2025/12/12 |
Product Introduction
Bioactivity
| Name | PSI-697 |
| Description | PSI-697 (P-Selectin Inhibitor) is an orally active P-selectin inhibitor with anti-inflammatory and anti-thrombotic effects, useful for studying cardiovascular diseases such as atherosclerosis. |
| In vitro | PSI-697 inhibits the binding of soluble human P-selectin to PSGL-1 in a concentration-dependent manner with IC50=50-125 μM. [1] |
| In vivo | In a rat model of surgical inflammation, PSI-697 (50 mg/kg, orally) significantly reduced rolling white blood cell count by 39% In a rat venous thrombosis model, PS-697 (100 mg/kg, orally) reduced thrombus weight by 18% relative to the carrier (P < 0.05) without prolonged bleeding time. In a rat model of carotid artery injury, PSI-697 (30 or 15 mg/kg oral) administered 1 hour before arterial injury and once daily thereafter for 13 days resulted in a dose-dependent reduction of 40.2% in the intima/media ratio. [1] In a venous thrombosis rat stenosis model, PSI-697 (30 mg/kg; The thickening of the intima of the venous wall was significantly reduced by daily oral force-feeding. [2] |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 40 mg/mL (108.75 mM), Sonication is recommended. |
| Keywords | PSI-697 | PSI 697 | P-selectin |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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