Q-VD-OPH NEW
| Price | $47 | $87 | $147 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-11-04 |
Product Details
| Product Name: Q-VD-OPH | CAS No.: 1135695-98-5 |
| Purity: 98.95% | Supply Ability: 10g |
| Release date: 2025/11/04 |
Product Introduction
Bioactivity
| Name | Q-VD-OPH |
| Description | Q-VD-OPh is an irreversible caspase inhibitor with an IC50 value of 48 nM against caspase-7 and between 25 and 400 nM against caspase-1, 3, 8, 9, 10, 12. Q-VD-OPh inhibits HIV infection and can cross the blood-brain barrier. |
| Cell Research | Caspase inhibitors are added at the indicated concentrations 30 minutes prior to the addition of apoptotic stimuli. Viability and cell number are determined by trypan blue exclusion from three random fields of greater than 200 cells/field. All experiments are performed a minimum of three times.(Only for Reference) |
| Kinase Assay | Enzyme assay is conducted in buffer containing 25 mM Tris, pH 8.0, 1 mM DTT, 1 mM spermine, 50 mM KCl, 0.01% Nonidet P-40, and 1 mM MgCl2. PARP reaction contains 0.1 μCi [3H]NAD+ (200?000 DPM), 1.5 μM NAD+, 150 nM biotinylated NAD+, 1 μg/mL activated calf thymus, and 1?5 nM PARP-1. Autoreactions utilizing SPA bead-based detection are carried out in 50 μL volumes in white 96-well plates. Compounds (e.g., MK-4827) are prepared in 11-point serial dilution in 96-well plate, 5 μL/well in 5% DMSO/Water (10× concentrated). Reactions are initiated by adding first 35 μL of PARP-1 enzyme in buffer and incubating for 5 min at room temperature and then 10 μL of NAD+ and DNA substrate mixture. After 3 h at room temperature, these reactions are terminated by the addition of 50 μL of streptavidin-SPA beads (2.5 mg/mL in 200 mM EDTA, pH 8). After 5 min, they are counted using a TopCount microplate scintillation counter. IC50 data is determined from inhibition curves at various substrate concentrations[1]. |
| In vitro | METHODS: The apoptosis of cardiomyocytes treated with Q-VD-OPH was detected by Flow Cytometry RESULTS: Q-VD-OPH could protect cardiomyocytes from virus-induced apoptosis. [1] |
| In vivo | METHODS: To study the effects of Q-VD-OPH on apoptosis, immune response, and virus replication, SIVmac251 virus was administered intravenously to Chinese macaques to mimic HIV infection, and Q-VD-OPH (20 mg/kg) was administered intravenously to Chinese macaques on days 5, 7, 9, 11, and 14. RESULTS: Q-VD-OPH significantly reduced the level of apoptosis of T cells in peripheral lymph nodes. The number of TUNEL+ cells was significantly lower in the Q-VD-OPh treated group than in the untreated group. Q-VD-OPH treatment significantly increased CD4+ T cell count and CD4/CD8 ratio and decreased viral replication. [2] METHODS: To study the protective effect of Q-VD-OPH on ischemic acute renal failure (ARF), Q-VD-OPH (120 mg/kg) was intraperitoneally injected into mice. RESULTS: Q-VD-OPH inhibited the expression of caspase-1 and IL-18 and neutrophil infiltration in ischemic ARF mice. [3] METHODS: To study the protective effect of Q-VD-OPH on myocardial injury, Q-VD-OPH (50 mg/kg) was intraperitoneally injected into virus-infected mice on days 3 to 6. RESULTS: Q-VD-OPH protected against virus-induced myocardial injury by inhibiting caspase activity. [1] METHODS: To study the therapeutic effect of Q-VD-OPH on AD, TgCRND8 mice were intraperitoneally injected with Q-VD-OPH (10 mg/kg) three times a week for three months. RESULTS: Q-VD-OPH inhibited caspase-7 activation and the pathological changes associated with tau protein, including caspase cleavage. [4] |
| Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 100 mg/mL (194.74 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (9.74 mM), Sonication is recommended. DMSO : 260 mg/mL (506.33 mM), Sonication is recommended. |
| Keywords | QVD-OPH | Q-VD-OPH | QVDOPH | Q VD OPH | Inhibitor | inhibit | Human immunodeficiency virus | HIVProtease | HIV Protease | HIV | Caspase-9 | Caspase-8 | Caspase-3 | Caspase-1 | Caspase |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Emtricitabine | Dolutegravir intermediate-1 | Dimethyl fumarate | Lamivudine | Probenecid | Chloroquine phosphate | Valproic Acid | Decanedioic acid | Dextran sulfate sodium salt (MW 5000) | Tenofovir |
| Related Compound Libraries | Apoptosis Compound Library | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Protease Inhibitor Library | Pyroptosis Compound Library | Anti-Viral Compound Library | Inhibitor Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Human Metabolite Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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