R 59-022 NEW
| Price | $32 | $72 | $128 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-11-10 |
Product Details
| Product Name: R 59-022 | CAS No.: 93076-89-2 |
| Purity: 98.55% | Supply Ability: 10g |
| Release date: 2025/11/10 |
Product Introduction
Bioactivity
| Name | R 59-022 |
| Description | R 59-022 (DKGI-I) is a diacylglycerol kinase (DGK) inhibitor and a 5-HT Receptor antagonist that blocks filovirus internalization in host cells. R 59-022 activates protein kinase C (PKC), inhibits intestinal smooth muscle contractility, and enhances O2- production induced by 1-oleoyl-2-acetylglycerol. |
| In vitro | Vero cells were treated with increasing concentrations of R 59-022 and exposed for 4 hours to MLV pseudotypes encoding LacZ and bearing EBOV GP or VSV-G in the presence of the drug. R 59-022 blocked an entry step specific to EBOV GP. Vero cells were treated with increasing concentrations of R 59-022 and exposed to VLPs bearing EBOV GP or VSV G in the presence of the drug for 3 h. By CCF2-AM staining and flow cytometry analysis, R 59-022 dose-dependent decrease in entry by the VLPs harboring the EBOV GP , IC50: ~2 µM. [5] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (4.35 mM), Sonication is recommended. DMSO : 50 mg/mL (108.79 mM), Sonication is recommended. |
| Keywords | serotonin | R 59-022 | R 59022 | R 59 022 | PKC | diacylglycerol kinase | DGK | 5HTReceptor | 5-HT Receptor | 5HT Receptor |
| Inhibitors Related | Alverine citrate | Dapoxetine hydrochloride | Cefaclor monohydrate | Clozapine N-Oxide | Mirtazapine | α-Vitamin E | 1,8-Cineole | Venlafaxine hydrochloride | Cloperastine hydrochloride | Trazodone hydrochloride | Mianserin hydrochloride | Cinchonidine |
| Related Compound Libraries | Bioactive Compound Library | Anti-Alzheimer's Disease Compound Library | Neuronal Signaling Compound Library | Neurotransmitter Receptor Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Fluorochemical Library | GPCR Compound Library | Serotonin Receptor-Targeted Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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