(R)-Fadrozole NEW
| Price | $1543 |
| Package | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-27 |
Product Details
| Product Name: (R)-Fadrozole | CAS No.: 102676-87-9 |
| Supply Ability: 10g | Release date: 2025/10/27 |
Product Introduction
Bioactivity
| Name | (R)-Fadrozole |
| Description | (R)-Fadrozole ((R)-CGS 16949A; FAD286) is a potent nonsteroidal inhibitor. (R)-Fadrozole also inhibits human placental aromatase (pIC 50 = 6.17) and aldosterone biosynthesis. (R)-Fadrozole reverses cardiac fibrosis in spontaneously hypertensive heart failure rats.. |
| In vitro | The (-)-enantiomer with the S-absolute configuration is responsible for the high aromatase inhibitory activity of (R)-Fadrozole[1]. |
| In vivo | Administration of (R)-fadrozole and (S)-fadrozole (0.24 and 1.2 mg/kg; daily; oral) consistently lowers plasma aldosterone levels. However, a reduction in the urinary aldosterone excretion rate was solely observed with (S)-fadrozole. Notably, (R)-fadrozole at the same dosages was effective in reducing preexisting left ventricular interstitial fibrosis by 50%, contrasting with canrenoate's 42% reduction. Unlike its isomer, (S)-fadrozole exhibited no antifibrotic effects. This study utilized SHHF rats, implementing a dosage regimen of 0.24 and 1.2 mg/kg administered orally on a daily basis, which led to decreased plasma aldosterone levels and a significant reversal of left ventricular interstitial fibrosis. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | FAD 286 | FAD-286 | CGS 16949A free base | (R) Fadrozole | CGS 16949A | (R)Fadrozole | Fadrozole |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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