(R)-Flurbiprofen Axetil NEW

(R)-Flurbiprofen Axetil

Product Information

• Product Code：F019051

• English Name：(R)-Flurbiprofen Axetil

• English Alias：(2R)-1-acetoxyethyl 2-(2-fluoro-[1,1'-biphenyl]-4-yl)propanoate

• CAS No.：2375240-97-2

• Molecular Formula：C₁₉H₁₉FO₄

• Molecular Weight：330.35

Advantages

• High Optical Purity：Confirmed by HPLC (ee ≥99.0%), NMR with chiral shift reagents, and X-ray crystallography, suitable for stereoisomer impurity analysis of Flurbiprofen Axetil.

• Stability Assurance：Stable for 36 months at -20℃ under light-protected, sealed storage; degradation rate <0.1% in ethanol-water solution within 6 months.

Applications

• Chiral Impurity Control：Used for UPLC-MS/MS detection of (R)-isomer in Flurbiprofen Axetil API and formulations, controlling optical impurity content to meet ICH Q3A standards (≤0.5%).

• Process Optimization Research：Monitors (R)-Flurbiprofen Axetil formed during asymmetric esterification, improving (S)-isomer selectivity by >90% via adjusting chiral catalyst dosage (e.g., Salen-Co complex) and temperature (0-5℃).

• Method Validation：Serves as a chiral standard for developing isomer separation methods, verifying UPLC resolution (≥3.5) and LOD (0.005 ng/mL).

Background Description

Research Status

• Detection Technology：UPLC-MS/MS with Chiralpak IB column (1.7μm) and n-hexane-ethanol (90:10) gradient elution achieves separation within 4 minutes, with LOD of 0.002 ng/mL for trace chiral impurity analysis.

• Formation Mechanism：Formed by reaction of flurbiprofen with (R)-1-acetoxyethanol under acidic catalysis (e.g., p-toluenesulfonic acid). Using enzymatic catalysis (e.g., porcine pancreatic lipase) or asymmetric hydrogenation reduces (R)-isomer formation by >85%.

• Safety Evaluation：In vitro cytotoxicity shows IC₅₀ of 78.6 μM against THP-1 cells ((S)-Flurbiprofen Axetil IC₅₀=8.2 μM), with low toxicity but requiring ≤0.5% limit. Accelerated stability testing is ongoing to monitor racemization rates under different pH conditions.

We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.

This product is intended for laboratory use only!

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E-mail: anna@molcoo.com

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