Ro 41-5253 NEW
| Price | $52 |
| Package | 1mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-11-04 |
Product Details
| Product Name: Ro 41-5253 | CAS No.: 144092-31-9 |
| Purity: 98.00% | Supply Ability: 10g |
| Release date: 2025/11/04 |
Product Introduction
Bioactivity
| Name | Ro 41-5253 |
| Description | Ro 41-5253 is an orally active RARα antagonist, ligand, and partial agonist of peroxisome proliferator-activated receptor (PPAR)-γ. It exhibits antitumor activity, inhibits proliferation, and induces apoptosis in MCF-7 and ZR-75.1 estrogen receptor-positive breast cancer cells. |
| In vitro | In human breast cancer cell lines MCF-7 and ZR 75.1, Ro 41-5253 (1 nM-10 μM; for 10 days) inhibited cell growth. At a concentration of 10 μM, the inhibition rate of MCF-7 cell growth was 81%, 30% at 1 μM, and no significant inhibition was observed at concentrations below 0.1 μM. For ZR 75.1 cells, the growth inhibition rate was 74% at 10 μM, 63% at 1 μM, and 42% at 0.1 μM[1]. |
| In vivo | In six-week-old athymic female Balb/c mice implanted with MCF-7 cell line, Ro 41-5253 (10, 30, 100, 300, and 600 mg/kg; oral gavage; once weekly; for 4 weeks) resulted in a reduction in tumor volume at doses of 10, 30, and 100 mg/kg, with no toxic side effects[2]. |
| Storage | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (165.07 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (6.81 mM), Sonication is recommended. |
| Keywords | Ro 41-5253 | Ro 41 5253 | RetinoidReceptor | Retinoid Receptor | RARα | Apoptosis |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Flubendazole | Cysteamine hydrochloride | Acetylcysteine | L-Glutamic acid monosodium salt monohydrate | Sodium 4-phenylbutyrate | L-Ascorbic acid | L-Glutamic acid | Tributyrin | L-Ascorbic acid sodium salt | Alginic acid |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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