Product Details
| Product Name:
Schisandrol B |
CAS No.:
58546-54-6 |
| Purity:
99.32% |
Supply Ability:
10g |
| Release date:
2025/12/09 |
Product Introduction
Bioactivity
| Name | Schisandrol B |
| Description | 1. Schisandrol B (Besigomsin) may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-κB and MAPKs signaling pathways. 2. Schisandrol B has anti-inflammatory property, potentially result from the inhibition of COX-2, iNOS, IL-6, TNF-α and NO through the down-regulation of RIP2 and NF-κB activation. 3. Schisandrol B induces marked protective effects against hepatic and renal injury induced by CCl(4) exposure through differential regulation of the MAPK signal transduction pathway. 4. Schisandrol B significantly inhibits cell proliferation in a dose-dependent manner, due to cell cycle arrest in the G1 phase with the downregulation of cyclin D1 expression and Retinoblastoma (RB) phosphorylation. |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (4.8 mM), Sonication is recommended.
DMSO : 50 mg/mL (120.06 mM), Sonication is recommended.
|
| Keywords | TJN101 | TJN 101 | Schisandrol B | ReactiveOxygenSpecies | Reactive Oxygen Species | P-glycoprotein | PCNA | p53 | p21 | lignan | Inhibitor | inhibit | Hepato-protective | Gomisin-A | Cytochrome P450 | CYPs | CYP3A11 | CYP2E1 | CCND1 | BCL-2 | Autophagy | antioxidant | anti-inflammatory | anti-diabetic |
| Inhibitors Related | Ethoxyquin | Kaolin | Stavudine | Aceglutamide | Allopurinol | Cysteamine hydrochloride | Hydroxychloroquine | Guanidine hydrochloride | Ethyl linoleate | Paeonol | Naringin | Alginic acid |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Traditional Chinese Medicine Monomer Library | Selected Plant-Sourced Compound Library | Anti-Cancer Clinical Compound Library | Natural Product Library | Drug Repurposing Compound Library | Neuroprotective Compound Library | Tobacco Monomer Library | Inhibitor Library | Anti-Aging Compound Library | Ancient Chinese Classical Formulas Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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