Seviteronel racemate NEW
| Price | $198 | $347 | $1140 |
| Package | 2mg | 5mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-08-21 |
Product Details
| Product Name: Seviteronel racemate | CAS No.: 1375603-36-3 |
| Supply Ability: 10g | Release date: 2025/08/21 |
Product Introduction
Bioactivity
| Name | Seviteronel racemate |
| Description | Seviteronel racemate is the racemate form of Seviteronel and is a potent inhibitor of CYP17 lyase. |
| In vivo | The MDA-PCa-133 xenograft, originating from a clinical castration-resistant prostate cancer (CRPC) bone metastasis, exhibits expression of PSA, the full-length androgen receptor (AR), and the AR-V7 isoform subcutaneously. In a study involving castrated male mice bearing the MDA-PCa-133 tumor, subjects were divided into three groups and underwent 25 days of oral treatment with either a vehicle, Seviteronel (VT-464) at 100 mg/kg twice daily, or Abiraterone Acetate (AA) at 100 mg/kg twice daily. Results demonstrated that both Seviteronel (VT-464) and AA significantly reduced tumor volume by more than two-fold relative to the vehicle group (p<0.05). The study highlights that Seviteronel’s (VT-464) selective CYP17 lyase inhibition is comparably effective to AA’s CYP17 inhibition in reducing tumor volume in this model [2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 50 mg/mL (125.21 mM), Sonication is recommended. |
| Keywords | VT-464, h-CYP17 Lyase | VT-464 | VT464 | VT 464 | Seviteronel racemate | racemate |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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