SIRT1-IN-3 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-27 |
Product Details
| Product Name: SIRT1-IN-3 | CAS No.: 2470969-91-4 |
| Supply Ability: 10g | Release date: 2025/10/27 |
Product Introduction
Bioactivity
| Name | SIRT1-IN-3 |
| Description | SIRT1-IN-3 (compound 3j) is a potent and selective inhibitor of silent information regulator 1 (SIRT1) with an IC50 of 4.2 μM [1]. |
| In vitro | SIRT1-IN-3 (compound 3j), at concentrations ranging from 0 to 100 μM over 48 hours, effectively inhibits the growth of several human cancer cell lines (including K562, HCT-116, H460, HepG2, A549, and MCF-7), demonstrating specific anti-proliferative properties. Moreover, this compound exhibits minimal cytotoxic effects on normal cell lines such as 293T and HUVEC. The cytotoxicity assay outcomes illustrate that the inhibition concentrations (IC50) for cancer cell lines K562, HCT-116, H460, HepG2, A549, and MCF-7 are 47, 41, 66, 93, 52, and 64 μM, respectively, indicating potency in a broad range of tumor types. Conversely, the IC50 values for non-cancerous 293T and HUVEC cells are relatively similar, at 49 and 45 μM, respectively, highlighting the compound's low toxicity toward normal human cells. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Inhibitors Related | JGB1741 | Sirtinol | Selisistat | Dihydrocoumarin | Nicotinamide riboside chloride | Resveratrol | SRT 2104 | Nicotinamide riboside | Perindopril erbumine | Fisetin | SIRT5 inhibitor 8 | Nicotinamide |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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