SP-96 NEW
| Price | $67 | $163 | $263 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-12-03 |
Product Details
| Product Name: SP-96 | CAS No.: 2682114-54-9 |
| Purity: 99.54% | Supply Ability: 10g |
| Release date: 2025/12/03 |
Product Introduction
Bioactivity
| Name | SP-96 |
| Description | SP-96 is a highly effective and selective inhibitor of Aurora B with an IC50 of 0.316 nM. SP-96 shows selective growth inhibition in NCI60 screening, including MDA-MD-468 (GI50=107 nM). SP-96 can be used in triple negative breast cancer studies. |
| In vitro | SP-96 (63.2 nM) inhibits Aurora B activity in H460 cells by the characteristics of increased DNA content, and it increases cell volume with enormous nucleus. SP-96 shows >2000 fold selectivity against FLT3 (IC50=1475.6 nM) and KIT (IC50=1307.6 nM). SP-96 (0-2 µM) inhibits Aurora A with IC50 value of 18.975 nM. SP-96 (0-1 µM; 24 hours) is not promiscuous, rather selective for a few cell lines, it inhibits MDA-MB-468, CCRF-CEM, COLO 205 and A498 cell growth with GI50 values of 107 nM,47.4 nM, 50.3 nM and 53.2 nM, respectively[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 95 mg/mL (209.50 mM), Sonication is recommended. |
| Keywords | Triple Negative | SP-96 | SP96 | SP 96 | NCI60 | Inhibitor | inhibit | hematopoiesis | Breast Cancer | AuroraKinase | Aurora Kinase | Aurora B |
| Inhibitors Related | Palmatine chloride | MK-8745 | SC-514 | Barasertib-HQPA | MBM-55S | KW-2449 | Ceftriaxone sodium hydrate | Palmatine | TAK-901 | Alisertib | CCT129202 | TCS7010 |
| Related Compound Libraries | Anti-Breast Cancer Compound Library | Post-Translational Modification Compound Library | Covalent Inhibitor Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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