Sparfosic acid trisodium NEW
| Price | Get Latest Price |
| Package | 1removed |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-11-04 |
Product Details
| Product Name: Sparfosic acid trisodium | CAS No.: 70962-66-2 |
| Supply Ability: 10g | Release date: 2025/11/04 |
Product Introduction
Bioactivity
| Name | Sparfosic acid trisodium |
| Description | Sparfosic acid trisodium is a CAD (carbamoyl-phosphate synthetase 2) inhibitor and also an aspartate transcarbamoyl transferase inhibitor with antitumour activity. |
| In vitro | Method: Br-1 and L-2 cell lines, established from metastases in nude mice injected with the human tumor cell line MDA-MB-435, were treated with Sparfosic acid trisodium (300 µM) for 12, 24, and 48 hours to evaluate its effects on the cell cycle. Result: Following treatment, both cell lines were predominantly arrested in the S phase, with a slightly higher proportion of S phase cells observed in L-2 compared to Br-1 cells. [1] |
| In vivo | Method: Sparfosic acid trisodium was administered intraperitoneally at a dose of 490 mg/kg on days 1, 5, and 9 to tumor-bearing mice implanted with either B16 melanoma or Lewis lung carcinoma, to evaluate its antitumor efficacy. Result: In the B16 melanoma model, Sparfosic acid trisodium extended mouse survival by 77%–86% compared to controls. In the Lewis lung carcinoma model, the compound showed high sensitivity; subcutaneous administration on days 1, 5, and 9 Resulted in a 50% cure rate in tumor-bearing mice. [3] |
| Storage | keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 160.00 mg/mL (577.41 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (18.04 mM), Sonication is recommended. H2O : 200.00 mg/mL (721.76 mM), Sonication is recommended. |
| Keywords | Sparfosic acid trisodium | Sparfosic acid |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Flubendazole | Cysteamine hydrochloride | Acetylcysteine | L-Glutamic acid monosodium salt monohydrate | Sodium 4-phenylbutyrate | L-Ascorbic acid | L-Glutamic acid | Tributyrin | L-Ascorbic acid sodium salt | Alginic acid |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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