Product Details
| Product Name:
ST 2825 |
CAS No.:
894787-30-5 |
| Supply Ability:
10g |
Release date:
2025/12/09 |
Product Introduction
Bioactivity
| Name | ST 2825 |
| Description | ST 2825 is a specific MyD88 dimerization inhibitor that blocks IL-1β-mediated activation of NF-κB transcriptional activity. |
| In vitro | ST2825 inhibits IL-1R/TLR signaling by disrupting MyD88 homodimerization in a concentration-dependent manner, achieving approximately 40% inhibition at 5 μM and 80% inhibition at 10 μM ST2825 [1]. |
| In vivo | ST2825 effectively reduces IL-1β-induced IL-6 production in mice through oral administration, showing significant inhibition at 100 and 200 mg/kg doses. Mice receive oral doses of ST2825 or vehicles, ranging from 50 to 200 mg/kg, five minutes before intraperitoneal (i.p.) injections of 20 μg/kg IL-1β [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 100 mg/mL (169.06 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween-80+45% Saline : 3.3 mg/mL (5.58 mM), Sonication is recommeded.
|
| Keywords | ST-2825 | ST2825 | ST 2825 | MyD88 |
| Inhibitors Related | Heclin | Smurf1-IN-A01 | EM 163 | D228 | Chloranil | TJ-M2010-5 | MyD88-IN-1 | T6167923 | Schaftoside | UF010 | DHBP | TLR1 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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