Swinholide A NEW
| Price | $290 |
| Package | 10μg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-09 |
Product Details
| Product Name: Swinholide A | CAS No.: 95927-67-6 |
| Supply Ability: 10g | Release date: 2025/10/09 |
Product Introduction
Bioactivity
| Name | Swinholide A |
| Description | Swinholide A is a polyketone compound that can be extracted from sponges and binds to actin to dimerize actin with Kd of about 50 nM. Swinholide A is a cytotoxin that stabilizes actin dimers and severs actin filaments. Swinholide A has antifungal activity and can damage the actin cytoskeleton of cells. |
| In vitro | First isolated from the Okinawan marine sponge Theonella swinhoei, Swinholide A dimerizes actin[1]. Isolated from the marine sponge Theonella swinhoei, Swinholide A is highly cytotoxic to a variety of cancer cell lines[2]. Disrupting the actin cytoskeleton of cells grown in culture, Swinholide A sequesters actin dimers in vitro in both polymerizing and non-polymerizing buffers, with a binding stoichiometry of one Swinholide A molecule per actin dimer. Additionally, it rapidly severs F-actin in vitro with high cooperativity[2]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Methanol : Soluble DMSO : Soluble Ethanol : Soluble |
| Keywords | Swinholide A | MK7684 | MK 7684 | Fungal |
| Inhibitors Related | Dehydroacetic acid sodium | Chlorobutanol hemihydrate | 2-Butyl-1,2-benzisothiazolin-3-one | Tebuconazole | Potassium gluconate | Chitosan (MW 150000) | Methyl 2-amino-5-bromobenzoate | Veratraldehyde | Paclobutrazol | Lauryl betaine | Geraniol | Sorbic acid |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $2.00/100kg |
VIP1Y
|
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
|
2025-08-07 | |
| $0.00/1kg |
VIP2Y
|
Shaanxi Xianhe Biotech Co., Ltd
|
2025-04-30 | |
| $0.00/1kg |
VIP1Y
|
Hefei Lbao Physical & Chemical Science Co.,Ltd
|
2025-11-19 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
INQUIRY