Tau-aggregation and neuroinflammation-IN-1 NEW
| Price | $38 | $73 | $118 |
| Package | 10mg | 25mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-12 |
Product Details
| Product Name: Tau-aggregation and neuroinflammation-IN-1 | CAS No.: 2175953-98-5 |
| Purity: 100% | Supply Ability: 10g |
| Release date: 2025/05/12 |
Product Introduction
Bioactivity
| Name | Tau-aggregation and neuroinflammation-IN-1 |
| Description | Tau-aggregation and neuroinflammation-IN-1 is a potent inhibitor of tau protein aggregates, showing significant inhibitory activity against AcPHF6 and full-length tau protein aggregates. It has anti-inflammatory activity, reduces NO release, exhibits low cytotoxicity against LSP-stimulated BV2 cells, and reverses okadaic acid-induced memory impairment in rats. |
| In vitro | Tau-aggregation and neuroinflammation-IN-1 (compound 30) (0-40 μM) reduces the survival of SH-SY5Y cells at 30 μM and exhibits no significant hepatotoxicity at high concentrations in LO2 cells, without affecting the viability of BV2 cells at 20 μM. Tau-aggregation and neuroinflammation-IN-1 (2.5, 5, and 10 μM; 24 h) maintain the anti-inflammatory effect of sodium usage and decrease the NO release rate by 41% at 10 μM in LPS-stimulated BV2 cells.[1] |
| In vivo | Tau-aggregation and neuroinflammation-IN-1 (5 and 10 mg/kg; I.P.; for 7 days, followed by 7 additional days post-OA injection; Male SD rats) significantly enhances spatial memory and cognitive abilities in OA-induced rats.[1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (108.59 mM), Sonication is recommended. |
| Keywords | Tau aggregation | NOSynthase | NO Synthase | NO | MicrotubuleAssociated | Microtubule Associated |
| Inhibitors Related | Flubendazole | L-NAME hydrochloride | Chondroitin sulfate | Mifepristone | 4-Isopropoxybenzoic acid | S-Methylisothiourea sulfate | Nitroarginine | Ethyl cinnamate | Methylene Blue trihydrate | L-Arginine hydrochloride | 4'-Demethylepipodophyllotoxin | Albendazole |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Microtubule-Targeted Compound Library | Neuroprotective Compound Library | Inhibitor Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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