Tenatoprazole sodium NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-27 |
Product Details
| Product Name: Tenatoprazole sodium | CAS No.: 335299-59-7 |
| Supply Ability: 10g | Release date: 2025/10/27 |
Product Introduction
Bioactivity
| Name | Tenatoprazole sodium |
| Description | Tenatoprazole sodium (TU-199 sodium) is a potent proton pump inhibitor that suppresses hog gastric H+/K+-ATPase activity, a key enzyme in acid secretion, with an IC50 value of 6.2 μM. |
| In vitro | Tenatoprazole, a prodrug in the proton pump inhibitor class, demonstrates inhibition of gastric H+/K+-ATPase activity in pigs with potency nearly equivalent to omeprazole, exhibiting IC50 values of 6.2 and 4.2 microM, respectively [1]. Upon activation by stomach acid in the secretory canaliculus of stimulated parietal cells, tenatoprazole transforms into an active sulfenamide or sulfenic acid. This active form establishes a disulfide bond with accessible cysteine residues on the gastric H+/K+-ATPase, effectively halting acid secretion. Notably, tenatoprazole associates with the acid pump's catalytic subunit with a binding ratio of 2.6 nmol per mg of enzyme [2]. |
| In vivo | Tenatoprazole effectively inhibits basal gastric acid secretion in pylorus-ligated rats in a dose-dependent manner, with an ED 50 value of 4.2 mg/kg orally. Additionally, at doses of 2.5 and 5 mg/kg intraduodenally, it suppresses gastric acid secretion induced by histamine, carbachol, or tetragastrin in gastric fistula rats. It also protects against various gastric and duodenal lesions induced by stress, pylorus ligation, indomethacin, and mepirizole. Notably, tenatoprazole achieves maximum enzyme binding of 2.9 nmol/mg 2 hours after intravenous administration, with binding sites located in the TM5/6 region at Cys813 and Cys822. The bioavailability of tenatoprazole is significantly enhanced in the (S)-tenatoprazole sodium salt hydrate form, showing a two-fold increase compared to its free form in dogs. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Inhibitors Related | Omeprazole | Chebulinic acid | Esomeprazole | Pantoprazole sodium | Esomeprazole Magnesium trihydrate | Abscisic Acid | Esomeprazole Magnesium | Pantoprazole Sodium Hydrate | Vonoprazan Fumarate | Lansoprazole | Zinc pyrithione | Esomeprazole Sodium |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $47.00/10mg |
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2025-11-10 | |
| $350.00/1KG |
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2020-07-13 | ||
| $0.00/1kg |
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Hangzhou ICH Biofarm Co., Ltd
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2023-07-11 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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