Product Details
| Product Name:
Tisolagiline |
CAS No.:
1894207-44-3 |
| Supply Ability:
10g |
Release date:
2025/11/10 |
Product Introduction
Bioactivity
| Name | Tisolagiline |
| Description | Tisolagiline (KDS2010) is a potent, highly selective and reversible MAO-B inhibitor with IC50=8 nM and oral activity for the treatment of Alzheimer's disease and obesity. |
| In vitro | Tisolagiline demonstrated high potency in inhibiting MAO-B in human cell assays, with an IC₅₀ of 8.0 nM, showing over 1,250-fold selectivity for MAO-B over MAO-A[1]. |
| In vivo | In a MPTP-induced Parkinson’s disease mouse model, oral administration of Tisolagiline (10 mg/kg/day for 5 days) significantly protected dopaminergic neurons in the substantia nigra and improved motor function. Furthermore, chronic administration in non-human primates (cynomolgus monkeys) showed favorable pharmacokinetics and safety at doses up to 100 mg/kg/day for 4 weeks, with reversible MAO-B inhibition and no significant adverse effects observed[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice./Shipping at ambient temperature. |
| Solubility Information | DMSO : 80.00 mg/mL (248.19 mM), Sonication is recommended.
|
| Keywords | Tisolagiline | MonoamineOxidase | Monoamine Oxidase | KDS-2010 |
| Inhibitors Related | Hydralazine hydrochloride | Safinamide | 1,4-Naphthoquinone | 4-Chlorochalcone | Paeonol | Hydroxylamine hydrochloride | Isatin | Methylene Blue | β-Aminopropionitrile | Amitraz | Allylthiourea | Tyramine |
| Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Drug Repurposing Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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